The integration of Christian Science theological principles and spiritual convictions with environmental, social, and governance (ESG) investing presents both profound opportunities and unique challenges for Christian Scientist nonprofit organizations, endowments, and foundations. Guided by the teachings of Mary Baker Eddy, especially in Science and Health with Key to the Scriptures, and the understanding of God as divine Principle, Socially Responsible Investing (SRI) in Christian Science contexts aims to align financial decisions with core values such as spiritual healing, integrity, universal brotherhood, and stewardship of creation. This comprehensive approach demands both financial prudence and deep moral integrity, creating a sophisticated framework that extends beyond simple exclusionary screening to actively embrace shareholder advocacy, community development, and impactful investing strategies that reflect Christian Scientist communal priorities and global responsibilities.